Spinal Muscular Atrophy, sma, sma disease, sma syndrome, crohn s disease, chrons disease
SMA in full form Spinal Muscular Atrophy is a crohns disease with multiple disorders, all having in common a genetic cause and the manifestation of weakness due to loss of the motor meurons of the spinal cord and brainstem.
The spinal muscular atrophy (sma), sma disease, sma syndrome, crohn s disease, chrons disease is becoming a real threat to many people.
What is sma or spinal muscular atrophy?
Spinal Muscular Atrophy or SMA Types I, II, and III belong to a group of hereditary diseases that cause weakness and wasting of the voluntary muscles in the arms and legs of infants and children.
The disorders are caused by an abnormal or missing gene known as the survival motor neuron gene (SMN1), which is responsible for the production of a protein essential to motor neurons. Without this protein, lower motor neurons in the spinal cord degenerate and die.
The type of SMA (I, II, or III) is determined by the age of onset and the severity of symptoms.
Type I (also known as Werdnig-Hoffman disease, or infantile-onset SMA) is evident at birth or within the first few months. Symptoms include floppy limbs and trunk, feeble movements of the arms and legs, swallowing difficulties, a weak sucking reflex, and impaired breathing.
Type II (also known as juvenile SMA, intermediate SMA, or chronic SMA, has an onset between 6 and 18 months. Legs tend to be more impaired than arms. Children with Type II are usually able to sit without support if placed in position. Some may be able to stand or walk with help.
Type III (also called Wolhlfart-Kugelberg-Welander disease, or mild SMA) can begin as early as the toddler years or as late as adolescence. Children can stand alone and walk, but may have difficulty getting up from a sitting position.
The spinal muscular atrophy (sma), sma disease, sma syndrome, crohn s disease, chrons disease is becoming a real threat to many people.
What is sma or spinal muscular atrophy?
Spinal Muscular Atrophy or SMA Types I, II, and III belong to a group of hereditary diseases that cause weakness and wasting of the voluntary muscles in the arms and legs of infants and children.
The disorders are caused by an abnormal or missing gene known as the survival motor neuron gene (SMN1), which is responsible for the production of a protein essential to motor neurons. Without this protein, lower motor neurons in the spinal cord degenerate and die.
The type of SMA (I, II, or III) is determined by the age of onset and the severity of symptoms.
Type I (also known as Werdnig-Hoffman disease, or infantile-onset SMA) is evident at birth or within the first few months. Symptoms include floppy limbs and trunk, feeble movements of the arms and legs, swallowing difficulties, a weak sucking reflex, and impaired breathing.
Type II (also known as juvenile SMA, intermediate SMA, or chronic SMA, has an onset between 6 and 18 months. Legs tend to be more impaired than arms. Children with Type II are usually able to sit without support if placed in position. Some may be able to stand or walk with help.
Type III (also called Wolhlfart-Kugelberg-Welander disease, or mild SMA) can begin as early as the toddler years or as late as adolescence. Children can stand alone and walk, but may have difficulty getting up from a sitting position.
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